Testosterone undecanoate – increase of oral bioavailability by nanostructured lipid carriers (NLC)

Testosterone undecanoate – increase of oral bioavailability by nanostructured lipid carriers (NLC)

Testosterone undecanoate (TU) has a low oral bioavailability of about 3 % in beagle dogs and 7 % in men. To avoid administration of a single dose in two oral units and to increase lymphatic absorption to minimise side effects in the liver, TU was incorporated into nanostructured lipid carriers (NLC) and formulated as drug nanocrystals. Testosterone (T) was run as nanocrystal formulation for rea...

Improvement of fluvastatin bioavailability by loading on nanostructured lipid carriers

The aim of this study is to prepare fluvastatin nanostructured lipid carriers (FLV-NLCs) in order to find an innovative way to alleviate FLV-associated disadvantages. The limitations include poor solubility and extensive first-pass metabolism, resulting in low (30%) bioavailability and short elimination half-life (1-3 hours). FLV-NLCs were prepared by hot emulsification-ultrasonication method. ...

Improvement of oral bioavailability of lovastatin by using nanostructured lipid carriers

Nanostructured lipid carriers (NLCs) have been one of the systems of choice for improving the oral bioavailability of drugs with poor water solubility. In the present study, lovastatin (LVT)-loaded NLCs (LVT-NLCs) were successfully prepared by hot high-pressure homogenization method with high entrapment efficiency, drug loading, and satisfactory particle size distribution. The particles had alm...

Oral bioavailability enhancement of agomelatine by loading into nanostructured lipid carriers: Peyer’s patch targeting approach

Agomelatine (AGM) is a new antidepressant drug with a novel mechanism of action and fewer side effects compared with older antidepressants. AGM is a melatonin receptor (MT1 and MT2) agonist and 5-hydroxytryptamine receptor (5-HT2C) antagonist. In the present study, the enhancement of the oral bioavailability of AGM was formulated and loaded into nanostructured lipid carriers (NLCs), using ultra...

Itraconazol-Loaded Nanostructured Lipid Carriers (NLC) for Pulmonary Application